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Researchers use zebrafish to study cancer-immune interactions Cancer researcher Rita Fior uses zebrafish to study human cancer. Though this may seem like an unlikely match, her work shows great promise with forthcoming applications in personalized medicine. The basic principle of Fior s approach relies on transplanting human cancer cells into dozens of zebrafish larvae. The fish then serve as living test tubes where various treatments, such as different chemotherapy drugs, can be tested to reveal which works best. The assay is rapid, producing an answer within four short days. Some years ago, when Fior was developing this assay, she noticed something curious. The majority of human tumor cells successfully engrafted in the fish, but some tumors didn t. They would just disappear within a day or two. However, when I treated the transplanted fish with chemotherapy, these tumors would not disappear anymore. They engrafted much more , she recalls.

Vanda povoaEmily hendersonNature communicationsChampalimaud centre for theRita fiorChampalimaud centreDoctoral studentImmune systemஎமிலி ஹென்டர்சன்இயற்கை தகவல்தொடர்புகள்ரீட்டா பீோர்முனைவர் மாணவர்நோய் எதிர்ப்பு சக்தி அமைப்புநோயெதிர்ப்பு சிகிச்சை